Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease.
Identifieur interne : 000B95 ( Main/Exploration ); précédent : 000B94; suivant : 000B96Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease.
Auteurs : Agathe Bridoux [France] ; Stephane Moutereau ; Ala Covali-Noroc ; Laurent Margarit ; Stephane Palfi ; Jean-Paul Nguyen ; Jean-Pascal Lefaucheur ; Pierre Césaro ; Marie-Pia D'Ortho ; Xavier DrouotSource :
- Nature and science of sleep ; 2013.
Abstract
Patients with Parkinson's disease frequently complain of sleep disturbances and loss of muscle atonia during rapid-eye-movement (REM) sleep is not rare. The orexin-A (hypocretin-1) hypothalamic system plays a central role in controlling REM sleep. Loss of orexin neurons results in narcolepsy-cataplexy, a condition characterized by diurnal sleepiness and REM sleep without atonia. Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown.
DOI: 10.2147/NSS.S41245
PubMed: 23847436
Affiliations:
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Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li></settlement></list><tree><noCountry><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Césaro">Pierre Césaro</name><name sortKey="Covali Noroc, Ala" sort="Covali Noroc, Ala" uniqKey="Covali Noroc A" first="Ala" last="Covali-Noroc">Ala Covali-Noroc</name><name sortKey="D Ortho, Marie Pia" sort="D Ortho, Marie Pia" uniqKey="D Ortho M" first="Marie-Pia" last="D'Ortho">Marie-Pia D'Ortho</name><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean-Pascal" last="Lefaucheur">Jean-Pascal Lefaucheur</name><name sortKey="Margarit, Laurent" sort="Margarit, Laurent" uniqKey="Margarit L" first="Laurent" last="Margarit">Laurent Margarit</name><name sortKey="Moutereau, Stephane" sort="Moutereau, Stephane" uniqKey="Moutereau S" first="Stephane" last="Moutereau">Stephane Moutereau</name><name sortKey="Nguyen, Jean Paul" sort="Nguyen, Jean Paul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stephane" last="Palfi">Stephane Palfi</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Bridoux, Agathe" sort="Bridoux, Agathe" uniqKey="Bridoux A" first="Agathe" last="Bridoux">Agathe Bridoux</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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